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Published on: April 25, 2025
A dimeric sulfonyl-γ-AApeptide for in vivo PET imaging of tumor VEGFR expression
Yu Yu Win1, Xiaoyan Li2,3, Jarais Fontaine1
1Department of Chemistry, University of South Florida, Tampa, FL, 33620, USA. jianfengcai@usf.edu.
Chemical Communications (Cambridge, England)
|September 17, 2026
Abstract:
Herein, we report the development of a sulfonyl-γ-AApeptide-based peptidomimetic radioligand acting as an antibody surrogate for VEGFR-targeted positron emission tomography (PET) imaging. The resulting radiotracer exhibited in vivo specificity toward VEGFR-positive 4T1 tumors.
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