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Updated: Sep 23, 2026

09:32
Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity
Published on: October 17, 2025
Targeting senescent cells with dipeptidyl peptidase 4-CAR-NK cells alleviates liver fibrosis and reverses metabolic
Rui Hua1, Kang Xu1, Huan Peng1
1Protein Science Key Laboratory of the Ministry of Education, School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China.
Acta Pharmaceutica Sinica. B
|September 21, 2026
Abstract:
Selective elimination of senescent hepatocytes by DPP4-CAR-NK cells could rescue liver fibrosis; therefore improving liver function and metabolic homeostasis in CCl4-induced liver fibrotic and naturally aged mice.
Keywords:
CAR-NKCell senescenceDPP4Eliminating senescent hepatocytesHSCs activationLiver fibrosisMetabolic homeostasisNaturally aged miceMore Related Videos
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