Thromborepair: the tissue repair partner to thromboinflammation

Platelets are small blood cells, historically viewed principally as mediators of hemostasis and thrombosis. However, it is now well established that platelets are pivotal modulators of the inflammatory response, establishing the concepts of thromboinflammation and immunothrombosis. Here, we propose the novel term "thromborepair" to describe how platelets promote tissue repair by facilitating leukocyte extravasation, resolving tissue inflammation, and coordinating fibrosis and angiogenesis. This review aims to discuss these processes and stimulate further exploration of platelet-based therapies to promote tissue repair.