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Cronkhite-Canada Syndrome Associated with Primary Cutaneous Peripheral T-cell Lymphoma and Membranous Nephropathy: A
Kohei Kiso1, Yusuke Shimoyama1, Saki Okuda-Hiwatashi2
1Division of Gastroenterology, Tohoku University Graduate School of Medicine, Japan.
Abstract:
Cronkhite-Canada syndrome (CCS) is a rare disorder characterized by gastrointestinal polyposis and ectodermal abnormalities. We report the case of a 64-year-old man with CCS complicated by primary cutaneous peripheral T-cell lymphoma (PC-PTCL) and membranous nephropathy. Cutaneous lymphoma was controlled using topical corticosteroids and phototherapy. During the clinical course of CCS, the patient developed proteinuria, and a renal biopsy revealed membranous nephropathy with equivocal phospholipase A2 receptor staining. Corticosteroid therapy improved both the gastrointestinal manifestations and proteinuria. This case suggests a possible immune-mediated association among CCS, PC-PTCL, and membranous nephropathy.