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Group A Streptococcus pharyngitis: 2025 clinical practice updates
1Julia L. Rogers is an Associate Professor at Purdue University Northwest College of Nursing in Hammond, IN; a family nurse practitioner at Northwest Health Pulmonary and Critical Care Medicine in Valparaiso, IN; and a family nurse practitioner with TEAM Health in Valparaiso, IN.
Abstract:
Group A Streptococcus (GAS) pharyngitis remains the leading bacterial cause of acute sore throat worldwide. Surges in GAS infections are driven by hypervirulent strains such as M1UK. The 2025 clinical practice guideline update from the Infectious Diseases Society of America introduces evidence-based recommendations for risk assessment using clinical scoring systems to optimize diagnostic testing and reduce unnecessary antibiotic use. This review examines current diagnostic approaches, treatment protocols, antimicrobial resistance patterns, and emerging therapeutic strategies to support nurse practitioners in delivering evidence-based, stewardship-aligned patient care.
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