Related Experiment Video
Updated: Sep 27, 2026

Surrogate Model Development for Digital Experiments in Welding
Published on: March 28, 2025
TURNING UP THE HEAT ON MASH MODELING
Maria E Moreno-Fernandez1, Senad Divanovic2
1Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; Divisions of Gastroenterology, Hepatology, and Nutrition.
Abstract:
In this issue, Leke et al. demonstrate that thermoneutral housing markedly accelerates Western diet-induced metabolic dysfunction-associated steatohepatitis (MASH), resulting in enhanced hepatic inflammation, fibrosis, and disease severity. Importantly, thermoneutral conditions produce a hepatic transcriptional landscape that more closely resembles human MASH than conventional housing. These findings further establish that providing homeostatic conditions via thermoneutral housing is an important element and a practical strategy for improving the translational relevance of preclinical MASH models.
More Related Videos
Related Concept Videos
Heating and Cooling Curves
For instance, the addition of heat raises the temperature of a solid; the amount of heat absorbed depends on the heat capacity of the solid (q = mcsolidΔT). According to thermochemistry, the relation between the amount of heat absorbed or released by a substance, q, and its...
Mechanisms of Heat Transfer II
Modeling and Similitude
Mechanisms of Heat Transfer I
Quantifying Heat
Mechanisms of Heat Transfer
Conduction, accounting for approximately 3% of body heat loss at rest, is the process of exchanging heat between molecules of two materials in direct contact. This can result in both heat loss and gain. For instance, when the body is submerged in water, which conducts heat 20 times more effectively than air, it can either lose or gain significant heat.

