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Engineering serum stable protein nanosheets with reduced macrophage uptake
Ishmamul Hoque Sadab1, Raka Chakraborty1, Kate A Kunst2
1School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332-0405, USA. julie.champion@chbe.gatech.edu.
Chemical Communications (Cambridge, England)
|September 28, 2026
Abstract:
Here, we engineer self-assembled planar micron-scale protein nanosheets through rational protein design. The protein nanosheets are stable in serum and evade macrophage uptake. These properties enable prolonged extracellular persistence, making them suitable extracellular protein carriers for local therapeutic applications.
