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Updated: Sep 30, 2026
Studying Pre-formed Fibril Induced α-Synuclein Accumulation in Primary Embryonic Mouse Midbrain Dopamine Neurons
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Targeting CH25H restores p62-mediated α-synuclein clearance
1Department of Pharmacology and Neuroscience Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore.
Abstract:
Astrocytes remove extracellular α-synuclein aggregates through p62-dependent autophagy, yet the factors limiting this defense remain unclear. Zhang and colleagues recently identified cholesterol 25-hydroxylase as an inducible negative regulator of p62-mediated clearance. Genetic suppression or a p62-derived decoy peptide reduced α-synuclein pathology in mouse models of Parkinson's disease.
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