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Updated: Oct 3, 2026

Establishment of a Segmental Femoral Critical-size Defect Model in Mice Stabilized by Plate Osteosynthesis
Published on: October 12, 2016
Segmental Bone Defects: Solutions to a Difficult Problem
Thomas J Chang1, Thomas H Jordan2, Kristina S Corley2
1Department of Podiatric Surgery, California School of Podiatric Medicine, Samuel Merritt University, Oakland, CA, USA.
Abstract:
Segmental bone loss in the foot and ankle-from infection, nonunion, avascular necrosis, or trauma-has long lacked reliable solutions, with historic femoral head allograft fusions achieving only approximately 50% union because revascularization often fails across defects larger than 2 cm. Newer 3 dimensional-printed custom metallic implants (titanium and cobalt chrome) bridge these defects with markedly higher integration rates (approximately 91% vs 61% for allografts). Total talus and hemitalus replacements restore hindfoot anatomy with promising short-term outcomes and good patient-reported measures. Success depends on correct implant sizing, robust beaming/plating fixation, and biomechanical planning for shear loaded medial and lateral colums.
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