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Updated: Oct 3, 2026

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
Published on: May 31, 2016
Rehabilitation Approaches to Cancer-related Fatigue
Deion Ellis1, Franchesca König1
1Department of Physical Medicine and Rehabilitation, University of Colorado, Anschutz Medical Campus, University of Colorado School of Medicine, Academic Office One, 12631 East 17th Avenue, Room 1201G, Aurora, CO 80045, USA.
Abstract:
Cancer-related fatigue (CRF) is a highly prevalent and functionally disabling symptom across the cancer continuum. Unlike typical fatigue, CRF is persistent, not proportional to recent activity, and rarely relieved by rest. Its etiology is multifactorial, involving immune dysregulation, mitochondrial dysfunction, neuroendocrine alterations, psychosocial stressors, and behavioral deconditioning. This article reviews the epidemiology, mechanisms, assessment tools, and rehabilitation strategies for CRF, with emphasis on the evidence base for exercise interventions. It also highlights emerging directions, including biomarker-driven therapy, tele-rehabilitation, and equity-focused models.
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