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Rethinking Common Diagnoses: Idiopathic Multicentric Castleman Disease Presenting as TAFRO Syndrome: A Case Report
Divita Rohatgi1, Annesha Chakraborty2, Sourav Kumar2
1Internal Medicine Hamdard Institute of Medical Sciences and Research Delhi India.
Clinical Case Reports
|October 2, 2026
Abstract:
Idiopathic multicentric Castleman disease (TAFRO subtype) can mimic common differentials. High suspicion is required for chronic systemic symptoms and generalized lymphadenopathy. As fine-needle aspiration is often non-diagnostic, early excisional biopsy is important. Rituximab-based therapy represents a guideline-supported alternative when anti-IL-6 treatment is unavailable or not feasible.