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Updated: Oct 7, 2026
Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
Published on: November 4, 2010
Using Asthma Phenotypes and Endotypes to Guide Treatment in Pediatric Asthma
Suzanne Y Ngo1, William C Anderson2
1Section of Allergy and Immunology, Department of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO, USA; Division of Pulmonary Allergy, and Critical Care, Department of Medicine, University of Colorado School of Medicine, 12700 East 19th Avenue, R2, B164, Room 10C03, Aurora, CO 80045, USA.
Abstract:
Understanding asthma phenotypes, including asthma severity and presence of type 2 (T2) inflammation, can help guide a personalized approach to treatment. Clinically accessible biomarkers, such as blood eosinophils, fractional exhaled nitric oxide, and immunoglobulin E, can help to differentiate between T2-high and non-T2 asthma phenotypes. For mild-to-moderate asthma, inhaled corticosteroids are the mainstay with best response in T2-high asthma. The addition of a long-acting β2-agnoist, however, is the best step-up option for most patients regardless of phenotype. Anti-inflammatory and single maintenance and reliever therapies are also emerging treatment options. For severe asthma, T2 status can guide biological treatment.
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