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Updated: Oct 7, 2026

Frailty Assessment in an Aging Mouse Model
Published on: September 23, 2025
Frailty: A Multidimensional Biopsychosocial Syndrome
Carl I Cohen1, Rivka Benyaminov1, Md Mamunur Rahman1
1SUNY Downstate Health Sciences University, 450 Clarkson Avenue, Brooklyn, NY 11203, USA.
Abstract:
The original conceptual landscape of frailty has evolved into a complex, multidimensional biopsychosocial syndrome. This has broadened the field to now include social and behavioral scientists and clinicians from a wide range of specialties. This article aims to provide an updated overview of this conceptual change by examining the emerging definitions of physical, cognitive, social, and psychological frailty; the tools used for diagnosis and assessment of these domains; the epidemiology of the domains; their pathogenesis, risk factors, and course; frameworks for prevention and treatment; and unresolved issues affecting the field.
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