A systematic analysis of gut microbiome characteristics in Chinese patients with gestational diabetes mellitus

To systematically analyze the change pattern of core gut microbiota in Chinese gestational diabetes mellitus (GDM) patients and provide basis for GDM early microecological screening and probiotic intervention.

Databases including PubMed, web of science, CNKI, and Wanfang were searched to identify reports on the association between gut microbiota and GDM. A quantitative system evaluation was conducted to assess the changes in core gut microbiota levels (such as Bifidobacterium, Lactobacillus, etc.) in GDM.

Totally, 31 studies involving 6,157 subjects were included. Systematic analysis revealed that levels of Bifidobacterium (SMD = -2.47, 95%CI: -2.86 to -2.09) and Lactobacillus (SMD = -1.82, 95% CI: -2.04 to -1.60) in the GDM were significantly lower than those in controls; while Enterobacteriaceae (SMD = 1.75, 95% CI: 1.53 to 1.98) and Enterococcus (SMD = 1.18, 95%CI: 1.03 to 1.32) were significantly higher than those in non-GDM. Sensitivity analysis shows that the above findings are relatively robust.

GDM exhibit significant gut microbiota dysbiosis. The reduction in Bifidobacterium and Lactobacillus and the increase in Enterobacteriaceae and Enterococcus may be important micro biological features for the onset and progression of GDM.