Related Experiment Video
Updated: Oct 11, 2026

Endoscopic Vacuum Therapy for the Treatment of Anastomotic Leakage after Total Gastrectomy with Esophagojejunostomy
Published on: August 22, 2025
Antibiotic resistance is associated with anastomotic leak after surgery for diverticular disease
Evelyn Londoño1, Ryan J Dieudonné2, Goda Savulionyte1
1Temple Department of Surgery, Philadelphia, PA, 19140, USA.
Introduction:
Patients with diverticulitis frequently receive multiple courses of antibiotics before surgery, which may promote antibiotic resistance. We hypothesized that antibiotic resistance is associated with anastomotic leak after surgery for diverticular disease.
Methods:
We retrospectively reviewed patients undergoing surgery for diverticular disease and linked microbiology data to our institution's National Surgical Quality Improvement Program database.
Results:
From 2016 to 2024, 159 patients underwent surgery for diverticular disease. The rates of anastomotic leak, infectious complications, and mortality were 9%, 29%, and 4%, respectively. Of the 101 (64%) patients with microbiology data, 40% had one or more organisms with antibiotic resistance. After logistic regression, antibiotic resistance was associated with a higher likelihood of anastomotic leak (OR 9.8, 95% CI 1.4-66.1, p = 0.019) and overall infectious complications (OR 3.3, 95% CI 1.3-8.6, p = 0.015).
Conclusions:
Among patients undergoing surgery for diverticular disease, having bacteria with clinically significant antibiotic resistance was associated with a higher likelihood of anastomotic leak and infectious complications.
Related Concept Videos
Diverticular Disease of the Colon
Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD:
Microbiota Modulation by Antibiotics
Development of Antibiotic Resistance
Mechanism of Antibiotic Resistance in MRSA
Clinical Significance of Antibiotic Resistance

