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Published on: December 3, 2019
SALL1 as a marker for distinguishing microglia from blood-derived myeloid cells in stroke brain scRNA-seq data
Chu-Yan Zhang1, Yi-Ming Lu1, Heng Zhang2
1Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education, China, School of Pharmacy, Nanjing Medical University, Nanjing, China.
Abstract:
Distinguishing resident microglia from infiltrating myeloid cells in stroke scRNA-seq data remains challenging due to shared myeloid markers; SALL1 shows greater specificity for microglia compared with commonly used markers (e.g. TMEM119, CX3CR1, P2RY12), and combining SALL1 with these commonly used markers improves the ability to distinguish microglia from infiltrating myeloid populations in stroke‑associated scRNA‑seq datasets.
