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Updated: Oct 22, 2026

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model
Published on: September 29, 2011
Stable-age sampling requires age-lifetime dependence in models of microbial pseudo-lag
Tiewu Tan1, Xin Zhang2, Hui Qin1
1Department of Intensive Care Medicine, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Changzhou, Jiangsu, 213000, China.
Abstract:
Stathas and Baranyi propose that inter-division-time variability and the excess of young cells in an exponentially growing culture generate a statistical pseudo-lag after transfer. The distinction between physiological lag and finite-inoculum stochasticity is useful. However, their simulation appears to draw relative age and total lifetime independently, although these variables are dependent in a stable exponentially growing population. Correct joint sampling changes the residual time to first division and means that stable age composition, by itself, should not displace ensemble-mean exponential growth. In addition, the Gamma parameter θ is used as a scale in the equations, as a rate in Figure 2 of Stathas and Baranyi (2026), and as a scale again in Figure 7 of Stathas and Baranyi (2026). We provide the correct joint distribution and parameter conversion and propose a focused reanalysis before the central quantitative claim is interpreted biologically.
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