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Updated: Oct 24, 2026
Dietary Supplementation of Polyunsaturated Fatty Acids in Caenorhabditis elegans
Published on: November 29, 2013
[Safety of diet therapy using ϖ-3 polyunsaturated fatty acids]
T I Bonkalo1, S A Derbeneva2, S V Shmeleva3
1Research Institute for Healthcare Organization and Medical Management of Moscow Healthcare Department, 115088, Moscow, Russia.
Objective:
to study the dose-dependent hypolipidemic effect of ϖ-3 polyunsaturated fatty acids (PUFAs) in patients with cardiovascular diseases.
Material And Methods:
An open, single-center, prospective study was conducted at the clinic of the Federal Research Center for Nutrition and Biotechnology. The tolerability, safety, and effectiveness of dietary therapy enriched with various sources of ϖ-3 PUFAs at dosages ranging from 300 to 3000 mg per day were evaluated in patients with cardiovascular diseases.
Results:
The study of different sources and dosages of ω-3 PUFAs demonstrated their good tolerability and safety, and revealed a dose-dependent effect on lipid profile parameters. The study demonstrated the dominant effect of different sources of ω-3 PUFAs on serum TG levels in patients with CVD.
Conclusion:
The results of this study suggest that the inclusion of ω-3 PUFAs in the basic diet of patients with CVD and hyperlipidemia has an additional anti-atherogenic effect.
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