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![Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-(phosphinetriyl)tripiperidine]}palladium Under Mild Reaction Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F51444.jpg&w=3840&q=50)
Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-(phosphinetriyl)tripiperidine]}palladium Under Mild Reaction Conditions
Published on: March 20, 2014
Phosphine-Mediated Decarboxylative C(sp3)-S Cross-Coupling of Aliphatic Carboxylic Acids Using Diaryl Disulfides as
Si-Yu Gao1, Xiao-Hui Ye1, Lan Yang1
1College of Sciences, Tianjin University of Science and Technology, Tianjin300457, P. R. China.
Abstract:
Herein, we report a phosphine-mediated decarboxylative thioetherification of aliphatic carboxylic acids. This method uses odorless diaryl disulfides as bifunctional reagents, activating aliphatic carboxylic acid substrates and providing a sulfur source. This strategy features mild conditions, is free of transition metals and photocatalysts, tolerates diverse functional groups, and enables the late-stage modification of bioactive molecules. Furthermore, mechanistic studies support a radical pathway involving thioester and NHPI ester intermediates.
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