Related Experiment Video
Updated: Oct 25, 2026
An Experimental Human DIEP Flap Model to Investigate Preservation Strategies for Vascularized Composite Allografts and Free Flaps
Published on: December 5, 2025
Chemotherapy and microsurgical-related vascular complications in DIEP flap breast reconstruction: A retrospective
Valdemar Kristoffer Storgaard Søndberg1, Marianne Djernes Lautrup1, Sinem Saritas1
1Department of Plastic and Breast Surgery, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, Aarhus N, 8240, Denmark.
Purpose:
To evaluate the association between preoperative chemotherapy and microsurgical vascular complications in patients undergoing deep inferior epigastric perforator (DIEP) flap breast reconstruction and whether chemotherapy timing affects risk.
Methods:
A retrospective cohort study was conducted at the Department of Plastic and Breast Surgery, Aarhus University Hospital, by including all patients who underwent DIEP flap breast reconstructions from January 2020 to October 2024. Reconstructions were grouped as exposed to preoperative chemotherapy (any chemotherapy before reconstruction) and compared to no preoperative chemotherapy (none or >90 days postoperatively). Data on predefined patient and tumor characteristics, intervention details, chemotherapy exposure, and microsurgical vascular complications were extracted from medical records and analyzed using univariate and multivariate logistic regression.
Results:
In total, 278 DIEP flap breast reconstructions were included. Preoperative chemotherapy was administered in 160 (57.6%) reconstructions, with a median interval of 641 days before reconstruction (IQR 410-924 days), whereas 118 (42.4%) reconstructions were performed without preoperative chemotherapy. No differences in the odds of vascular complications, including reanastomosis, hematoma, flap loss, composite vascular outcome, infection, or minor complications were observed between the groups, in either univariate or multivariate analyzes. The interval between chemotherapy and surgery was not associated with vascular complications.
Conclusion:
In this cohort, most reconstructions were performed long after chemotherapy exposure, and preoperative chemotherapy and time from chemotherapy to DIEP flap breast reconstruction were not associated with microsurgery-related vascular complications. These findings support the safety of reconstruction in this setting. Larger multicenter studies are warranted to validate the role of chemotherapy timing and specific regimens.
