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Updated: Oct 25, 2026

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets
Published on: May 11, 2015
Lipid metabolism and pulmonary arterial hypertension
Yuanyuan Sun1, Peipei Gao2, Chunyi Lv3
1Department of Respiratory and Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250000, China; Department of Rehabilitation, Shanghai Pulmonary Hospital Affiliated to Tongji University, Shanghai 200433, China.
Abstract:
Pulmonary arterial hypertension (PAH) is a rare and progressive disease characterized by pulmonary vascular remodeling and progressive narrowing of the pulmonary arteries. Recent studies have shown that changes in lipid metabolism and lipid action play an important role in the pathogenesis of PAH, involving membrane integrity, energy metabolism, inflammatory response, and pulmonary vascular remodeling. Lipoprotein receptor deficiency further exacerbates inflammation, fibrosis, and associated pathological processes in PAH. This review summarizes the role of many lipid-active substances and their signaling pathways in the pathogenesis of PAH, sorting the biomarkers related to the severity and prognosis of PAH and discussing the potential application of drug therapy targeting lipid metabolism in managing PAH. This review aims to identify clinically relevant lipid molecules and candidate biomarkers, and to provide new insights and potential targets for precision oriented diagnosis and treatment of PAH.
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