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Updated: Oct 25, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Photo-Induced Three-Component Radical Trifluoromethylation/Heteroarylation of Alkenes via EDA Complexes
Zhijun Zhu1, Xiaopeng Hai1, Yuyu Lv1
1College of Chemistry and Chemical Engineering, Northwest Normal University, No 976 Anning East Road, Lanzhou730070, China.
Abstract:
This study develops a visible-light-induced electron donor-acceptor (EDA) complex strategy, employing the inexpensive and readily available DBU as the electron donor and the industrially available CF3Br as the trifluoromethyl source, to achieve the trifluoromethylation/heteroarylation of alkenes. This method offers advantages in cost-effectiveness and facile postreaction processing, without requiring transition metals or fluorescent dyes as photocatalysts. Moreover, nitrogen-containing heterocycles such as quinoxalinones, uracils, and pyrazines are all compatible in this transformation through C-H alkylation, providing a convenient and economical new avenue for the green late-stage modification of nitrogen-containing heterocyclic compounds.
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