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Updated: Oct 25, 2026
![[(DPEPhos)(bcp)Cu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
[(DPEPhos)(bcp)Cu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Remote Generation of Pyramidalized N-N Axial Chirality via a Copper-Catalyzed Friedel-Crafts Reaction
Hao Zhu1, Kuaikuai Xu1, Wenkun Luo1
1School of Chemistry and Pharmaceutical Engineering, Changsha University of Science and Technology, Changsha410114, China.
Abstract:
We report a Cu/bisoxazoline-catalyzed desymmetrization via Friedel-Crafts alkylation, facilitating the remote construction of N-N axial chirality with a central carbon stereocenter. The operational robustness is underscored by scale-up reactions and versatile postsynthetic transformations. X-ray crystallography verifies a pyramidalized nitrogen center deviating 20° from planarity, while thermal racemization experiments establish strong configurational stability. This strategy provides a general platform for developing pyramidalized N-N atropisomers.
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