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Updated: Oct 25, 2026

Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
Meta-Selective Phenylselenylation of Pyridines through Oxazino Azines
Huiqiang Li1, Wenxia Hu1, Dongxu Xie1
1Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education and Yunnan Province Center for Research & Development of Natural Products, School of Pharmacy; Yunnan Key Laboratory of Cross-Border Infectious Disease Control and Prevention and Novel Drug Development; Southwest United Graduate School, Yunnan University, Kunming, 650500, P. R. China.
Abstract:
A metal-free and TCCA-promoted highly regioselective meta-C-H bond phenylselenylation of pyridines using bench-stable dearomatized oxazino azines has been developed. A substantial variety of 3-(phenylselanyl)pyridines were obtained under open-air and mild conditions, with a maximum yield of 90%. The scalable process was also available from pyridine directly in a "one-pot" version and was used in the late-stage meta-phenylselenylation of pyridine-containing drugs and natural product derivatives, providing an efficient platform for diverse meta-selective selenylfunctionalization of pyridine frameworks.
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