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Updated: Oct 25, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Catalytic Desymmetrizing Carbonyl-Amine Condensation Reaction to Construct Axially Chiral Diaryl Ethers
Tao Huang1, Ze-Xin Zhou1, Hui-Ling Zhou1
1Key Laboratory of Green Catalysis of Jiangxi Education Institutes, Jiangxi Normal University, Nanchang, Jiangxi330022, China.
Abstract:
Catalytic desymmetrizing carbonyl-amine condensation (CAC) reactions between prochiral 2,6-diamino diaryl ethers and cyclobutane-1,3-diones have been developed for the highly enantioselective synthesis of axially chiral diaryl ethers in up to 99% ee values. This reaction represents the first application of prochiral aromatic amines in catalytically asymmetric CAC reactions. Control experiments revealed that cyclobutane-1,3-diones showed an obviously higher reactivity and enantioselectivities in these asymmetric CAC reactions.
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