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Updated: Oct 25, 2026

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Ligand Accelerated Palladium-Catalyzed C-H Arylation of Electron-Deficient Polyfluoroarenes with Aryl Bromides
Srinivasarao Tenneti1, Nageswara Rao Kalikinidi1, Arun D R Shada1
1TCG GreenChem, Inc., 701 Charles Ewing Blvd, Ewing, New Jersey08628, United States.
Abstract:
A ligand accelerated highly efficient palladium-catalyzed C-H arylation of electron-deficient polyfluoroarenes with aryl and heteroaryl bromides has been developed. The reaction proceeds efficiently under mild conditions with low catalyst loading (0.25 mol % Pd) and ligand loading (0.275 mol %), affording a broad range of fluorinated biaryl products in good to excellent yields. The methodology exhibits a wide substrate scope and good functional group tolerance. Its synthetic utility is demonstrated through the concise synthesis of several industrially relevant molecules, highlighting the practicality, efficiency, and scalability of the catalytic system.
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