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Updated: Oct 25, 2026

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Nickel-Catalyzed Tandem Dimerization/Hydroheteroarylation of Isoprenes with Heteroarenes
Wen-Hui Jin1, Rong-Chen Duan1, Wei-Can Qiu1
1Key Laboratory of Organic Synthesis of Jiangsu Province & State Key Laboratory of Bioinspired Interfacial Materials Science, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou215123, China.
Abstract:
Herein, we report the first nickel-catalyzed tandem dimerization/hydroheteroarylation of isoprenes with indoles, using a catalytic system consisting of a heteroleptic Ni(II) complex Ni(IPr*OMe)[P(OEt)3]Br2 and a base NaOtBu. This system provides easy access to a range of C2-substituted cyclic monoterpenoid indoles with high regioselectivity under solvent-free conditions. This tandem transformation shows good compatibility with indoles bearing various functional groups, such as esters, acetals, silanes, and boronate esters. The tandem transformation is also applicable to other heteroarenes, including pyrroles, (benzo)thiophenes, (benzo)furans, benzimidazoles, pyrazoles, quinazolones, imidazo[1,2-a]pyridines, and pyridines.
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