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Updated: Oct 25, 2026

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Palladium-Catalyzed Benzylic-Selective Hydroaminocarbonylation of Internal Alkenes
Fei Wu1, Hui-Yi Yang1, Ruo-Yu Wang1
1Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an710127, P. R. China.
Abstract:
Owing to the low reactivity of internal alkenes, their hydrocarbonylation is largely confined to isomerization-hydrocarbonylation reactions. Herein, a palladium-catalyzed benzylic-selective hydroaminocarbonylation of internal alkenes with aniline hydrochlorides is reported. A broad range of internal alkenes and anilines are compatible with the reaction, affording α-aryl carboxylic amides in high yields with high regioselectivity. The synthetic utility is illustrated by the gram-scale synthesis and concise preparation of key pharmaceutical intermediates and bioactive molecules.
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