Related Experiment Video
Updated: Oct 25, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
Asymmetric Access to Structurally Complex 1-Tetralols through Diels-Alder Cycloadditions of Photogenerated
María González-Marcos1, José Trujillo-Sierra1, Enara Esteban1
1Departamento de Química Orgánica/Institute of Organic Synthesis and Centro de Innovación en Química Avanzada (ORFEO-CINQA), Universidad de Alicante, 03080-Alicante, Spain.
Abstract:
Photoenolization/Diels-Alder (PEDA) reactions provide a rapid approach to highly substituted 1-tetralols. Herein, we report a PEDA strategy using activated acrylate-based dienophiles for the synthesis of densely functionalized 1-tetralols with high diastereoselectivity. Isatin-derived acrylates enable access to spirocyclic architectures, while chiral auxiliary-based acrylates allow an asymmetric variant, providing enantioenriched 1-tetralol derivatives with efficient stereocontrol.
More Related Videos
Related Concept Videos
Cycloaddition Reactions: Overview
Diels–Alder Reaction Forming Cyclic Products: Stereochemistry
[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction
Cycloaddition Reactions: MO Requirements for Photochemical Activation
Diels–Alder Reaction Forming Bridged Bicyclic Products: Stereochemistry
Cycloaddition Reactions: MO Requirements for Thermal Activation
![Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60786.jpg&w=3840&q=50)
