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Updated: Oct 25, 2026
![Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-(phosphinetriyl)tripiperidine]}palladium Under Mild Reaction Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F51444.jpg&w=3840&q=50)
Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-(phosphinetriyl)tripiperidine]}palladium Under Mild Reaction Conditions
Published on: March 20, 2014
Electrochemical Nickel-Catalyzed Cross-Electrophile Coupling: A Sustainable Platform for C(sp3)-C(sp3)/C(sp2) Bond
Yong-Fei Huang1, Jinxia Li2, Miao Yan3
1Jiangxi Provincial Key Laboratory of Organic Functional Molecules, Institute of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang330013, China.
Abstract:
An electrochemical nickel-catalyzed cross-electrophile coupling reaction of organic halides with cyclosulfonium salts to construct C(sp3)-C(sp3)/C(sp2) bonds is reported. This highly selective synthetic approach demonstrates significant practical utility, as evidenced by its broad substrate scope encompassing C(sp3)-/C(sp2)-iodides, while maintaining excellent functional group tolerance, particularly challenging late-stage functionalization applications. Moreover, density functional theory (DFT) calculations are employed to systematically evaluate the Gibbs free energy profile of key intermediates along the proposed nickel-catalyzed reaction pathway, thereby providing robust theoretical support for the mechanistic feasibility of the transformation.
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