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Updated: Oct 28, 2026
Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
Published on: April 11, 2012
Review of a "Bone Glue Fixation" development
1Department of Materials Science and Engineering , Applied Materials Science Division, Uppsala University, Uppsala, Sweden; Biomimetic Innovations Ltd, Shannon, Ireland.
Abstract:
The paper presents some of the background to the development of bone glues. Whilst there have been many attempts over the last 100 years to find a safe and effective biomimetic adhesive biomaterial it is only recently that promising and feasible candidates have been developed. In particular a formulation based on a combination of an amino acid, phosphoserine (PSer), together with calcium salts and water, has demonstrated the potential to meet clinically defined requirements for a bone adhesive (Osstic®). This bone glue has achieved first in human use after having demonstrated consistent preclinical performance.
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Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...