The Symptom and Domain Structure of Psychotic Disorders: A Network Analysis Approach

Little is understood about the symptom network structure of psychotic disorders. In the current study, we aimed to examine the network structure of psychotic symptoms in a broad and transdiagnostic sample of subjects with psychotic disorders (n = 2240) and to determine whether network structure parameters vary across demographic, sampling method and clinical variables. Gaussian graphical models were estimated for 73 psychotic symptoms assessed using the Comprehensive Assessment of Symptoms and History. A 7-cluster solution (reality distortion, disorganization, catatonia, diminished expressivity, avolition/anhedonia, mania, and depression) best explained the underlying symptom structure of the network. Symptoms with the highest centrality estimates pertained to the disorganization and, to a lesser extent, negative domains. Most bridge symptoms pertained to the disorganization domain, which had a central position within the network and widespread connections with other psychopathological domains. A comparison of networks in subgroups of subjects defined by premorbid adjustment levels, treatment response, and course pattern significantly influenced both network global strength and network structure. The sampling method and diagnostic class influenced network structure but not network global strength. Subgroups of subjects with less densely connected networks had poorer outcomes or more illness severity than those with more densely connected networks. The network structure of psychotic features emphasizes the importance of disorganization symptoms as a central domain of psychopathology and raises the possibility that interventions that target these symptoms may prove of broad use across psychopathology. The network structure of psychotic disorders is dependent on the sampling method and important clinical variables.