Sources of chemical information used in antibiotic certification

Because of a legislative mandate requiring the predistribution testing and certification of each batch of antibiotics produced for human use in the U.S.A., the National Center for Antibiotics Analysis (NCAA) must utilize a wide variety of techniques for establishing its official methods. Methods adapted from material submitted by the manufacturers in Forms 5 and 6, as well as from other sources, such as literature searches, the NCAA reprint collection, and cross reference file are described.