Hidradenitis Suppurativa-Associated Squamous Cell Carcinoma of the Groin: A Clinicopathologic Analysis
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Noelle Desir1, Iain Noel Encarnacion1, Kevin Puerta Durango1
1Drs. Desir, Encarnacion, Durango, Obeng-Nyarko, Ogunleye, Taylor, and Weir are from the Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia. Dr. Desir also is from Weill Cornell Medical College, New York, New York. Dr. Encarnacion also is from Eastern Virginia Medical School, Norfolk, Virginia. Dr. Durango also is from the Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire. Dr. Obeng-Nyarko also is from the College of Medicine, Florida State University, Tallahassee. Dr. Jackson is from the College of Human Medicine, Michigan State University, Grand Rapids.
Abstract:
Cutaneous squamous cell carcinoma (cSCC) is the second most common nonmelanoma skin cancer and the second leading cause of skin cancer-related death worldwide. Hidradenitis suppurativa (HS) is a chronic inflammatory follicular skin disease that causes notable impairment on quality of life. Although cSCC is a rare complication of HS, the mechanisms underlying malignant transformation remain poorly understood. We conducted a retrospective clinicopathologic analysis of 4 patients with cSCC arising in primary perianal/gluteal HS lesions. All patients had a history of smoking, suggesting a potential role for environmental risk factors, while no significant association with human papillomavirus (HPV) was identified. Tumor differentiation varied from poorly to well differentiated, demonstrating the heterogeneity of HS-associated cSCC and the importance of individualized management.