Transcriptomic data of larval zebrafish exposed to environmentally relevant levels of uranyl nitrate and sodium arsenite

Uranium (U) and arsenic (As) are both ubiquitous contaminants in the American southwest, posing risks to humans, animals, and the environment. Depleted uranium's (DU) chronic effects and mechanisms of toxicity are incompletely understood. Differential gene expression of concomitant exposures to identify markers of toxicity have not been undertaken until now. Continuous low-dose, high-dose, and concomitant exposures are investigated using the larval zebrafish (Danio rerio), with exposure paradigms lasting from embryo collection until sampling at 5 days post fertilization (dpf). Herein, we describe overall differential gene expression with counts and pathway enrichment statistics using both gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. The raw dataset has been deposited in NCBI's Gene Expression Omnibus (GEO) repository [1] under the accession number GSE319292 [2] and can be used to further nominate molecular initiating events following chemical exposure.