Klotho Gene Single-Nucleotide Polymorphism and Proteinuria in a General Population
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Masato Hamasaki1, Kazuhiko Kotani1,2, Yoshitaka Iwazu2,3
1Center for Community Medicine, Jichi Medical University, Shimotsuke-City, Tochigi 329-0498, Japan.
Background:
Chronic kidney disease (CKD) is a major condition with a substantial sociomedical and economic burden. Klotho plays a role in renal protection via its antioxidant and anti-inflammatory properties. Proteinuria is an early indicator of CKD. Although experimental studies have demonstrated the biological effects of Klotho in CKD, its clinical relevance to proteinuria remains unclear.
Methods:
The present study investigated the association between the A/T alleles of the Klotho gene rs650439 single-nucleotide polymorphism (SNP) and proteinuria in a general Japanese population. Clinical and genotyping data from a total of 916 community-dwelling participants (mean age = 63 years old) were analyzed.
Results:
Participants carrying the minor TT genotype accounted for 13.2% of the population. The prevalence of proteinuria was significantly higher in the TT group than in the AA + AT group (15.7% vs. 7.3%, P < 0.01). Logistic regression analysis showed that the TT genotype was significantly associated with proteinuria (crude odds ratio (OR) = 2.37, 95% confidence interval (CI) 1.35-4.14). This association remained significant after adjustment for age, sex, and cardiometabolic factors (adjusted OR = 2.07, 95% CI 1.14-3.77).
Conclusions:
These findings suggest that the TT genotype of Klotho gene rs650439 SNP may serve as a genetic marker for early renal proteinuria. Further research is required to confirm the findings.
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