Compounding Through Crisis: Developing Safe Processes During Drug Shortages
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Updated: Nov 2, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Mallory Wolman1, Peter H Nguyen2
1Massachusetts General Hospital, Boston, Massachusetts. mwolman@mgh.harvard.edu.
Abstract:
This article explores the challenges associated with formulation development during drug shortages, including literature evaluation, formulation design, beyond-use date assignment, documentation, quality review, operationalization, and interdisciplinary collaboration. Through real-world examples and practical strategies, it highlights the ingenuity and adaptability required of today's compounding pharmacists while advocating for greater collaboration, shared knowledge, and infrastructure to better support formulation development during future supply disruptions.
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