Routine LC-MS/MS Screening for Cocaine and Opiates in Whole Blood
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Updated: Nov 2, 2026
High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
Susana Simões1, Luana M Rosendo1,2,3, João M Franco1
1Serviço de Química e Toxicologia Forenses, Delegação do Sul, Instituto Nacional de Medicina Legal e Ciências Forenses, I. P., 1169-201, Lisboa, Portugal.
Abstract:
This study describes a method for the analysis of cocaine, its metabolites, and opioids in whole blood samples using protein precipitation, followed by detection with liquid chromatography-tandem mass spectrometry (LC-MS/MS). This method utilizes low sample volumes (0.1 mL) and minimizes matrix effects for enhanced sensitivity and reproducibility. Samples are prepared straightforwardly, ensuring a reliable and fast workflow for forensic toxicological applications.
