Reframing QSP: AI-Driven Multi-Modal Data as a New Measurement Layer
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1Integrated Mechanistic & Data Driven Modelling Group, Department of Drug Design and Pharmacology, Copenhagen University, Copenhagen, Denmark.
Abstract:
Quantitative systems pharmacology (QSP) provides a mechanistic framework for integrating biological and pharmacological knowledge in drug development. Simultaneously, advances in artificial intelligence (AI), particularly in multi-modal data analysis, are transforming how biological information is derived. I argue that AI should not be viewed as a data integration tool, but as a new layer of quantitative measurement generation. This reframing positions QSP as a foundational model of biology, used here in a conceptual rather than technical sense, and AI as a source of quantitative inputs.
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