[Research on obstructive sleep apnea and sleep bruxism]

Objective:The aim of this study was to explore the potential causal relationship between obstructive sleep apnea（OSA） and sleep bruxism（SB） through Mendelian randomization（MR） analysis, a method widely used in genetic research. Methods:We extracted genetic instrumental variables for OSA from the publicly available GWAS catalog database and for SB from the FinnGen database. We designed bidirectional two-sample MR analyses to comprehensively assess the genetic association of OSA with SB. We performed MR analyses using inverse variance weighting（IVW）, weighted median, MR-Egger, Simple Mode, and Weighted Mode, as well as sensitivity analyses to assess whether the results were robust. Results:OSA had no significant effect on SB（OR=1.71, 95%CI 0.67-4.32, P＝0.26>0.05）, reverse MR analysis similarly failed to find a significant association between SB and OSA（OR=1.01, 95%CI 0.99-1.03, P＝0.39>0.05）. Conclusion:This MR analysis found no genetic evidence of bidirectional causality between OSA and SB, and the results of this study do not support the existence of a direct, reciprocal pathogenic effect between OSA and SB.