CT-guided percutaneous lung biopsy under calm breathing
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Updated: Nov 4, 2026

Robotic-assisted Bronchoscopy Combined with Multimodal Imaging for Targeted Lung Cryobiopsies
Published on: July 19, 2024
Meiru Wen1, Ailin Chen1, Zhiqiang Peng1
1Department of Radiology, Ganzhou Cancer Hospital, Ganzhou, Jiangxi, People's Republic of China.
Objectives:
To investigate the use of syringe needle-assisted localization to enable patients to undergo CT-guided percutaneous lung biopsy performed under calm breathing. This approach was developed to facilitate CT-guided lung biopsy in patients who have difficulty performing breath-holding maneuvers and to improve procedural feasibility under calm breathing conditions.
Methods:
A total of 200 patients who underwent CT-guided percutaneous lung biopsy were included and randomly allocated to either a syringe needle-assisted calm breathing group (n=100) or a conventional breath-holding group (n=100). Procedural outcomes, including puncture success rate, procedure-related complications (pneumothorax, pulmonary hemorrhage, hemothorax, chest wall hematoma, and air embolism), and the number of needle adjustments, were collected and compared between the two groups.
Results:
No statistically significant differences were detected in puncture success rate or complication rates. The calm breathing group showed a tendency toward fewer needle adjustments, although the statistical interpretation differed between the primary mean-based analysis and the non-parametric sensitivity analysis.
Conclusions:
CT-guided percutaneous lung biopsy under calm breathing with syringe needle-assisted localization was feasible in the present study and may be useful for patients who have difficulty cooperating with breath-holding instructions.
