Clot in Transit
Related Experiment Video
Updated: Nov 5, 2026

Tracking Fibrinolysis of Chandler Loop-Formed Whole Blood Clots Under Shear Flow in An In-Vitro Thrombolysis Model
Published on: April 19, 2024
Deepika Potarazu1, Sana Sultana2, Seth I Sokol3
1Division of Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Abstract:
Clot in transit, defined as a mobile right heart thrombus, is a rare but life-threatening manifestation of venous thromboembolism. Its presence in acute pulmonary embolism is associated with high mortality and hemodynamic instability. Diagnosis relies primarily on echocardiography, with adjunctive roles for computed tomography and cardiac magnetic resonance. Management remains challenging due to the absence of randomized trials. Treatment options include anticoagulation alone, systemic thrombolysis, surgical embolectomy, and catheter-based interventions, with outcomes favoring active reperfusion in unstable patients. Multidisciplinary decision-making is essential, and ongoing research aims to clarify optimal strategies to improve survival in this high-risk population.
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