Sustained 177Lu-FAPI-2286 Retention in Graves' Orbitopathy
Related Experiment Video
Updated: Nov 11, 2026
![Automated Preparation of [68Ga]Ga-3BP-3940 on a Synthesis Module for PET Imaging of the Tumor Microenvironment](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F68356.jpg&w=3840&q=50)
Automated Preparation of [68Ga]Ga-3BP-3940 on a Synthesis Module for PET Imaging of the Tumor Microenvironment
Published on: April 25, 2025
Mohammad Umar1, Nishikant Avinash Damle1, Madhavi Tripathi1
1Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.
Abstract:
A 39-year-old man suffering from Graves' ophthalmopathy, which was resistant to steroids (with a clinical activity score of 5/7 and a moderate-severe EUGOGO grade), had a 68Ga-FAPI-46 PET/CT scan. This scan showed strong bilateral FAPI activity in the extraocular muscles, especially in the inferior recti, even though his visual acuity remained normal. A later low-dose 177Lu-FAPI-2286 retention study confirmed that the radiotracer stayed selectively within the recti. This example suggests that fibroblast activation protein-targeted theranostics could be a new way to image and possibly treat Graves' orbitopathy.
Related Concept Videos
Graves Disease II: Pathophysiology
Graves' Disease I: Introduction
Positron Emission Tomography
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Drug Distribution: Tissue Binding
For...
