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Lanthanide markers in a single sample for nutrient studies in humans.

D P Hutcheson, B Venugopal, D H Gray

The Journal of Nutrition

|April 1, 1979

Summary

Lanthanide markers offer a new method for tracking nutrient intake and utilization. This technique, using fecal analysis, accurately measures nutrients like energy, fat, protein, and calcium.

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Area of Science:

Biochemistry
Analytical Chemistry
Nutrition Science

Background:

Accurate determination of nutrient intake and utilization is crucial for nutritional assessment.
Traditional methods can be complex and time-consuming.
Development of novel marker-based approaches is needed.

Purpose of the Study:

To develop and validate a method for determining nutrient intake and apparent utilization using lanthanide markers.
To assess the feasibility of using fecal analysis with non-absorbed markers for nutrient tracking.

Main Methods:

Terbium oxide was administered as an intake marker.
Samarium, scandium, ytterbium, and europium oxides served as nutrient-specific markers incorporated into foods.
Fecal samples were collected and analyzed for nutrient and marker concentrations.
Fecal marker concentration stabilization was observed within 2 days, allowing for single grab sample analysis after 3 days.

Main Results:

The ratio of nutrient marker to nutrient intake and excretion allowed for calculation of apparent nutrient utilization.
No significant differences were found when comparing the lanthanide marker method with direct methods for gross energy, fat, protein, and calcium.
The marker method demonstrated stability and reliability for nutrient analysis.

Conclusions:

Lanthanide markers provide a valid and efficient procedure for determining nutrient intake and apparent utilization.
This method simplifies nutrient analysis, enabling the assessment of multiple nutrients simultaneously.
The findings support the use of this technique in nutritional research and assessment.

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