Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Peroxidase-mediated virucidal systems.

M E Belding, S J Klebanoff, C G Ray

    Science (New York, N.Y.)
    |January 9, 1970
    PubMed
    Summary
    This summary is machine-generated.

    The peroxidase-halide-hydrogen peroxide system shows potent antiviral activity against polio and vaccinia viruses, especially at low pH. This enzyme system may play a role in the body

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Don't run roughshod over behavioral healthcare. Trauma-related needs can't be ignored as they were in past tragedies.

    Behavioral healthcare tomorrow·2002
    Same author

    Stimulation of human neutrophils and monocytes by staphylococcal phenol-soluble modulin.

    Journal of leukocyte biology·2001
    Same author

    Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin.

    Journal of immunology (Baltimore, Md. : 1950)·2000
    Same author

    Vaginal myeloperoxidase and flora in the pig-tailed macaque.

    Journal of medical primatology·2000
    Same author

    NFAT1 enhances HIV-1 gene expression in primary human CD4 T cells.

    Clinical immunology (Orlando, Fla.)·2000
    Same author

    Myeloperoxidase.

    Proceedings of the Association of American Physicians·1999
    Same journal

    Erratum for the Research Article "Detecting supramolecular organic nanoparticles during heat wave".

    Science (New York, N.Y.)·2026
    Same journal

    Local signals, systemic decline.

    Science (New York, N.Y.)·2026
    Same journal

    The mechanics of liver regeneration.

    Science (New York, N.Y.)·2026
    Same journal

    Computing in a memory with physics.

    Science (New York, N.Y.)·2026
    Same journal

    Retraction.

    Science (New York, N.Y.)·2026
    Same journal

    Making time.

    Science (New York, N.Y.)·2026
    See all related articles

    Area of Science:

    • Biochemistry
    • Virology
    • Immunology

    Background:

    • Peroxidases, hydrogen peroxide, and halides are key components of host defense mechanisms.
    • Viral infections pose significant public health challenges, necessitating novel therapeutic strategies.

    Purpose of the Study:

    • To investigate the virucidal efficacy of the peroxidase-halide-hydrogen peroxide system against specific viruses.
    • To explore the potential role of this system in host defense against viral infections.

    Main Methods:

    • In vitro assays were used to assess the virucidal activity of the peroxidase-halide-hydrogen peroxide system.
    • Experiments were conducted across a range of pH conditions, with a focus on low pH.

    Main Results:

    Related Experiment Videos

  • The peroxidase-halide-hydrogen peroxide system demonstrated potent virucidal activity against poliovirus and vaccinia virus.
  • Optimal virucidal activity was observed at a low pH.

    • Conclusions:

    • The peroxidase-halide-hydrogen peroxide system is a potent antiviral agent effective against poliovirus and vaccinia virus.
    • This enzymatic system may contribute to innate immunity and host defense against viral pathogens.