Related Experiment Videos
Lantadene A toxicity in sheep. A model for cholestasis
Pathology
|January 1, 1979
Summary
Lantadene A from Lantana camara causes liver injury in sheep. This study establishes lantadene A as a hepatotoxin, useful for modeling cholestasis.
Area of Science:
- Toxicology
- Veterinary Medicine
- Hepatology
Background:
- Lantana camara is a tropical plant known for its toxicity.
- Lantadene A is identified as the toxic principle responsible for liver injury.
Purpose of the Study:
- To investigate the hepatotoxicity of lantadene A in sheep.
- To establish a disease model for intrahepatic cholestasis.
Main Methods:
- Intravenous injection of varying doses of lantadene A into sheep.
- Monitoring of serum enzymes and bilirubin levels.
- Observation of histological changes in liver tissue.
Main Results:
- Single high doses of lantadene A induced hepatocellular injury and hepatic necrosis.
- Repeated low doses resulted in a cholestatic syndrome mimicking plant-induced disease.
- Lantadene A demonstrated direct hepatotoxicity, independent of alimentary metabolism.
Conclusions:
- Lantadene A is a potent hepatotoxin in sheep.
- The study provides a valuable animal model for investigating intrahepatic cholestasis.
- Lantadene A's toxicity is confirmed, with implications for understanding plant-induced liver disease.