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Related Experiment Videos

Does curare affect transmitter release?

A Auerbach, W Betz

    The Journal of Physiology
    |March 1, 1971
    PubMed
    Summary
    This summary is machine-generated.

    Curare, a neuromuscular blocking agent, does not significantly affect the amount of neurotransmitter released by nerve stimuli in frog and rat muscles. Its primary action is postsynaptic blockade.

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    Area of Science:

    • Neuroscience
    • Pharmacology
    • Muscle Physiology

    Background:

    • Neuromuscular transmission involves the release of neurotransmitters from motor neurons to muscle fibers.
    • Curare is known for its postsynaptic blocking action at the neuromuscular junction.
    • Understanding curare's presynaptic effects is crucial for its clinical application.

    Purpose of the Study:

    • To investigate the effect of curare on the quantity of neurotransmitter released by nerve stimulation.
    • To differentiate between presynaptic and postsynaptic effects of curare.
    • To quantify potential alterations in quantal content at the neuromuscular junction.

    Main Methods:

    • Electrophysiological techniques, including voltage clamp and microelectrode recordings, were used.

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  • Experiments were conducted on frog sartorius nerve-muscle preparations and rat diaphragm preparations.
  • Methods to block muscle twitching (glycerol treatment, muscle fiber cutting) were employed to facilitate measurements.

    • Main Results:

    • Low doses of curare reduced miniature end-plate potential and end-plate current amplitudes equally, indicating no change in quantal release.
    • Higher doses of curare did not significantly alter estimated quantal content in frog muscle.
    • Accounting for experimental artifacts in rat diaphragm preparations also showed no significant effect of curare on quantal content.

    Conclusions:

    • Curare's primary effect is postsynaptic blockade.
    • Curare does not significantly alter the amount of neurotransmitter released presynaptically.
    • Any presynaptic effect of curare is considerably smaller than its postsynaptic action.