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Related Experiment Video

Updated: May 7, 2026

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

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Published on: November 27, 2016

Bacteria, bile salts, and intestinal monosaccharide malabsorption.

M Gracey, V Burke, A Oshin

|September 1, 1971

Summary

Bacterial overgrowth in the small intestine impairs monosaccharide transport, leading to malabsorption. This defect is linked to increased deconjugated bile salts from an abnormal anaerobic flora.

Area of Science:

Gastroenterology
Microbiology
Cell Biology

Background:

Intestinal bacterial overgrowth can disrupt normal digestive processes.
The jejunal blind loop model is used to study the effects of altered gut environments.

Purpose of the Study:

To investigate the impact of jejunal blind loops on intestinal monosaccharide transport.
To correlate transport defects with changes in bacterial flora and bile salt conjugation.

Main Methods:

Studied monosaccharide (arbutin, D-fructose) transport in vitro and in vivo in rats with jejunal blind loops.
Analyzed bacterial flora composition and bile salt conjugation status.
Examined small intestinal epithelium ultrastructure.

Main Results:

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Monosaccharide transport was impaired in blind-loop rats, most significantly in the blind loop itself.
The severity of transport defects correlated with anaerobic bacterial density.
Abnormal bile salt deconjugation and epithelial cell damage were observed.

Conclusions:

Bacterial contamination of the upper gut impairs intestinal monosaccharide absorption.
Deconjugated bile salts, produced by abnormal anaerobic flora, are implicated in this transport defect.