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Related Experiment Videos

Disopyramide-induced ventricular fibrillation.

W J Nicholson, C E Martin, J G Gracey

    The American Journal of Cardiology
    |May 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Disopyramide medication can cause ventricular fibrillation, a serious heart rhythm disturbance. This risk is similar to quinidine, suggesting disopyramide should be discontinued if this adverse effect occurs.

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    Area of Science:

    • Cardiology
    • Pharmacology
    • Electrophysiology

    Background:

    • Disopyramide is an antiarrhythmic medication.
    • Ventricular fibrillation is a life-threatening cardiac arrhythmia.

    Observation:

    • Three patients developed ventricular fibrillation shortly after receiving disopyramide.
    • Electrocardiograms revealed prolonged Q-T intervals or prominent U waves.

    Findings:

    • Disopyramide can induce ventricular fibrillation.
    • The cardiac electrical changes observed are similar to those seen with quinidine.

    Implications:

    • Disopyramide-induced ventricular fibrillation necessitates drug discontinuation.
    • This finding highlights the importance of cardiac monitoring during disopyramide therapy.