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Subacute spongiform encephalopathy. Electron microscopic studies.

J J Bubis, Y Goldhammer, J Braham

    Journal of Neurology, Neurosurgery, and Psychiatry
    |December 1, 1972
    PubMed
    Summary
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    Electron microscopy revealed large vacuoles in brain cells and dense-core vesicles in two subacute spongiform encephalopathy cases. These findings offer insights into the cellular pathology of this neurological disorder.

    Area of Science:

    • Neuropathology
    • Electron Microscopy
    • Neurodegenerative Diseases

    Background:

    • Subacute spongiform encephalopathies are fatal neurodegenerative conditions.
    • Understanding the ultrastructural changes is crucial for diagnosis and research.

    Purpose of the Study:

    • To describe the electron microscopic findings in brain biopsies from two patients with subacute spongiform encephalopathy.
    • To characterize the nature of vacuoles and vesicles observed in affected neurons and astrocytes.

    Main Methods:

    • Electron microscopy was performed on brain biopsy samples.
    • Detailed ultrastructural analysis of cellular morphology, including vacuoles and vesicles.

    Main Results:

    • Large vacuoles were observed within astrocytic and neuronal processes, characterized by concentric membranes.

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  • Dense-core vesicles were identified in axonal endings and neuronal perikarya.
  • These vesicles may represent catecholamine-containing organelles.

    • Conclusions:

    • The study details specific ultrastructural alterations in subacute spongiform encephalopathy.
    • The presence of concentric membrane-bound vacuoles and dense-core vesicles provides morphological markers.
    • Further investigation is warranted to confirm the identity and role of these vesicles in the disease process.